Tuesday, August 25, 2020
Galileo vs. Church
Galileo is seen as the dad of present day science since he made and tried speculations which we despite everything pass by in the present years. In the current day we are thought and live by the heliocentric hypothesis. This essentially implies the sun in the inside and the planets are in its circle. The Roman Catholic Church accepted that the earth was in the middle, subsequently the sun and different planets were in the Earthââ¬â¢s circle. Galileo was charged of bogus educating. The charge against Galileo was grounded on a report that Galileo had been by and by requested in 1616 not to talk about Copernicanism either orally or in writing.Cardinal Bellarmine had passed on, however Galileo created a declaration marked by the cardinal, expressing that Galileo had been exposed to no further limitation than applied to any Roman Catholic under the 1616 order. No marked report repudiating this was ever found, however Galileo was constrained in 1633 to stay away from and was condemned t o life detainment The Dialog was requested to be scorched, and the sentence against him was to be perused freely in each university.At the time, the congregation was the lawful authority of the land and anything that conflicted with the congregation's regulation of what the Bible stated, was viewed as blasphemy and deserving of banning, detainment, or passing. For this situation Galileo abused the convention of the Roman Catholic Church by showing the heliocentric hypothesis. As per the congregation these theoryââ¬â¢s by Galileo was attempting to refute the book of scriptures. The more grounded side is Galileoââ¬â¢s side. As I would like to think I would pick Galileoââ¬â¢s contention over the congregation since he attempted to disclose to the congregation his findings.The church being loaded up proudly and determined didn't allow Galileo to clarify and uncover his discoveries since they naturally thought he was conflicting with the holy book and attempting to refute it. The y at that point indicted him. Taking everything into account, Galileo is known as the dad of current science, his hypothesis which was disregarded in the past is currently acknowledged and thought in the current day. This shows the Roman Catholic Church was one-sided before and would not like to allow him to uncover and clarify his discoveries.
Saturday, August 22, 2020
General George Washington in the American Revolution
General George Washington in the American Revolution Conceived February 22, 1732, along Popes Creek in Virginia, George Washington was the child of Augustine and Mary Washington. An effective tobacco grower, Augustine additionally got engaged with a few mining adventures and filled in as Justice of the Westmoreland County Court. Starting at a youthful age, George Washington started investing the vast majority of his energy at Ferry Farm close to Fredericksburg, VA. One of a few youngsters, Washington lost his dad at age eleven. Accordingly, he went to class locally and was instructed by mentors as opposed to following his more seasoned siblings to England to select at the Appleby School. Leaving school at fifteen, Washington thought about a vocation in the Royal Navy however was hindered by his mom. In 1748, Washington built up an enthusiasm for reviewing and later acquired his permit from the College of William and Mary. After a year, Washington utilized his familys associations with the incredible Fairfax tribe to acquire the situation of assessor of recently framed Culpeper County. This demonstrated a rewarding post and permitted him to start purchasing land in the Shenandoah Valley. The early long periods of Washingtons work likewise observed him utilized by the Ohio Company to overview land in western Virginia. His vocation was additionally helped by his stepbrother Lawrence who told the Virginia state army. Utilizing these ties, the 62 Washington went to the consideration of Lieutenant Governor Robert Dinwiddie. Following Lawrences passing in 1752, Washington was made a significant in the local army by Dinwiddie and appointed as one of four region auxiliaries. French Indian War In 1753, French powers started moving into the Ohio Country which was guaranteed by Virginia and the other English settlements. Reacting to these attacks, Dinwiddie dispatched Washington north with a letter training the French to leave. Meeting with key Native American pioneers in transit, Washington conveyed the letter to Fort Le Boeuf that December. Accepting the Virginian, the French commander,à Jacques Legardeur de Saint-Pierre, declared that his powers would not pull back. Coming back to Virginia, Washingtons diary from the undertaking was distributed on Dinwiddies request and helped him gain acknowledgment all through the state. After a year, Washington was set order of a development gathering and sent north to help in building a fortification at the Forks of the Ohio. Helped by the Mingo boss Half-King, Washington traveled through the wild. En route, he discovered that a huge French power was at that point at the forks developing Fort Duquesne. Building up a base camp at Great Meadows, Washington assaulted a French exploring party drove by Ensign Joseph Coulon de Jumonville, at the Battle of Jumonville Glen on May 28, 1754. This assault provoked a reaction and a huge French power moved south to manage Washington. Building Fort Necessity, Washington was strengthened as he arranged to meet this new threat.â In the subsequent Battle of Great Meadows on July 3, his order was beaten and eventually compelled to give up. Following the destruction, Washington and his men were allowed to come back to Virginia. These commitment started the French Indian War and prompted the appearance of extra British soldiers in Virginia. In 1755, Washington joined Major General Edward Braddocks advance on Fort Duquesne as a volunteer assistant to the general.â In this job, he was available when Braddock was seriously crushed and slaughtered at the Battle of the Monongahela that July. In spite of the disappointment of the crusade, Washington performed well during the fight and worked enthusiastically to mobilize British and frontier forces.â In acknowledgment of this, he got order of the Virginia Regiment. In this job, he demonstrated a severe official and coach. Driving the regiment, he energetically protected the outskirts against the Native Americans and later participated in the Forbes Expedition which caught Fort Duquesne in 1758. Peacetime In 1758, Washington surrendered his bonus and resigned from the regiment. Coming back to private life, he wedded the well off widow Martha Dandridge Custis on January 6, 1759, and took up habitation at Mount Vernon, a manor he had acquired from Lawrence. With his recently acquired methods, Washington started extending his land possessions and significantly extended the manor. This likewise observed him enhance its tasks to incorporate processing, angling, materials, and refining. In spite of the fact that he never had offspring of his own, he helped in bringing up Marthas child and girl from her past marriage. As one of the colonys wealthiest men, Washington started serving in the House of Burgesses in 1758. Moving to Revolution Throughout the following decade, Washington developed his business advantages and impact. In spite of the fact that he despised the 1765 Stamp Act, he didn't start freely contradicting British duties until 1769 when he composed a blacklist because of the Townshend Acts. With the presentation of the Intolerable Acts following the 1774 Boston Tea Party, Washington remarked that the enactment was an intrusion of our privileges and benefits. As the circumstance with Britain crumbled, he led the gathering at which the Fairfax Resolves were passed and was chosen to speak to Virginia at the First Continental Congress. With the Battles of Lexington Concord in April 1775 and the start of the American Revolution, Washington started going to gatherings of the Second Continental Congress in his military uniform. Driving the Army With the Siege of Boston continuous, Congress shaped the Continental Army on June 14, 1775. Because of his experience, eminence, and Virginia roots, Washington was designated as president by John Adams. Tolerating hesitantly, he rode north to take order. Showing up at Cambridge, MA, he found the military severely muddled and lacking supplies. Setting up his central command at the Benjamin Wadsworth House, he attempted to arrange his men, acquire required weapons, and improve the fortresses around Boston. He likewise dispatched Colonel Henry Knox to Fort Ticonderoga to bring the establishments firearms to Boston. In a gigantic exertion, Knox finished this crucial Washington had the option to emplace these weapons on Dorchester Heights in March 1776. This activity constrained the British to relinquish the city.â â Keeping an Army Together Perceiving that New York would probably be the following British objective, Washington moved south in 1776. Restricted by General William Howe and Vice Admiral Richard Howe, Washington was constrained from the city in the wake of being flanked and crushed at Long Island in August. In the wake of the destruction, his military barely got away back to Manhattan from its fortresses in Brooklyn. In spite of the fact that he won a triumph at Harlem Heights, a series of thrashings, including at White Plains, saw Washington driven north then west across New Jersey. Intersection the Delaware, Washingtons circumstance was urgent as his military was severely decreased and selections were lapsing. Requiring a triumph to reinforce spirits, Washington directed a challenging assault on Trenton on Christmas night. Moving Towards Victory Catching the towns Hessian army, Washington lined up this triumph with a triumph at Princeton a couple of days after the fact before entering winter quarters. Remaking the military through 1777, Washington walked south to square British endeavors against the American capital of Philadelphia. Meeting Howe on September 11, he again flanked and beaten at the Battle of Brandywine. The city fell soon after the battling. Looking to switch things around, Washington mounted a counterattack in October however was barely crushed at Germantown. Pulling back to Valley Forge for the winter, Washington set out on a monstrous preparing program which was administered by Baron Von Steuben. During this period, he had to suffer interests, for example, the Conway Cabal, in which officials tried to have him expelled and supplanted with Major General Horatio Gates. Rising up out of Valley Forge, Washington started a quest for the British as they pulled back to New York. Assaulting at the Battle of Monmouth, the Americans battled the British to a halt. The battling saw Washington at the front working indefatigably to revitalize his men. Seeking after the British, Washington subsided into a free attack of New York as the focal point of the battling moved toward the southern provinces. As president, Washington attempted to coordinate procedure on different fronts from his central command. Joined by French powers in 1781, Washington moved south and attacked Lieutenant General Lord Charles Cornwallis at Yorktown. Getting the British acquiescence on October 19, the fight adequately finished the war. Coming back to New York, Washington persevered through one more year of battling to keep the military together in the midst of an absence of assets and supplies. Later Life With the Treaty of Paris in 1783, the war reached a conclusion. Despite the fact that hugely famous and in position to turn into a despot on the off chance that he wanted, Washington surrendered his bonus at Annapolis, MD on December 23, 1783, affirming the point of reference of non military personnel authority over the military. In later years, Washington would fill in as leader of the Constitutional Convention and as the primary President of the United States. As a military man, Washingtons genuine worth came as a persuasive pioneer who demonstrated equipped for keeping the military together and keeping up obstruction during the darkest days of the contention. A key image of the American Revolution, Washingtons capacity order regard was just outperformed by his eagerness to surrender power back to the individuals. At the point when he learned of Washingtons renunciation, King George III expressed: If he does that, he will be the best man on the planet.
Thursday, July 30, 2020
Writing to Sell Yourself How A Tailored Resume Can Help You Land the Job You Want!
Writing to Sell Yourself How A Tailored Resume Can Help You Land the Job You Want! Writing to Sell Yourself: How A Tailored Resume Can Help You Land the Job You Want! Writing to Sell Yourself: How A Tailored Resume Can Help You Land the Job You Want! Wading through pools of applicants and sifting through piles of resumes are necessary evils for any employer when searching for the perfect potential new hire. Studies show that recruiters will spend just seconds on an applicantâs resume before accepting or rejecting what they see. They are looking for individuals who have the necessary skills to contribute to their organizationâ"hopefully one who will stay for the long term and who will grow and develop over time. In order for an employer to take your application to the next level, you must first give them a reason to stop and take a look at you. When you individualize your cover letter to a particular employer, you show that you are committed to being part of their team; youâve invested the time researching their company and what they want, and you can highlight why you are the perfect person for the job. A common problem when writing a cover letter is simple: most of us donât want to sound too boastful about our skills, talents, and accomplishments. But wait! If you donât, who will? The job market is a competitive place and there are plenty of other candidates who are ready to play. Remember, you are essentially selling yourself when applying for any jobâ"so donât be afraid to stand out. If you want to succeed and go far, the first step is to provide an appealing written representation of your employability. Writing a cover letter is hard work, but the writers at Homework Help USA can help get you where you want to go. A well written cover letter crafted by our talented writers will help you in your search for a new full-time or part-time job; if the job search is stressing you out, get in touch with us and let us offer you some relief on the writing side. References: Harris, Peter. (2015, May 5). How to write a resume for a high-paying job (with sample). Retrieved August 20, 2015, from Writing to Sell Yourself How A Tailored Resume Can Help You Land the Job You Want! Writing to Sell Yourself: How A Tailored Resume Can Help You Land the Job You Want! Writing to Sell Yourself: How A Tailored Resume Can Help You Land the Job You Want! Wading through pools of applicants and sifting through piles of resumes are necessary evils for any employer when searching for the perfect potential new hire. Studies show that recruiters will spend just seconds on an applicantâs resume before accepting or rejecting what they see. They are looking for individuals who have the necessary skills to contribute to their organizationâ"hopefully one who will stay for the long term and who will grow and develop over time. In order for an employer to take your application to the next level, you must first give them a reason to stop and take a look at you. When you individualize your cover letter to a particular employer, you show that you are committed to being part of their team; youâve invested the time researching their company and what they want, and you can highlight why you are the perfect person for the job. A common problem when writing a cover letter is simple: most of us donât want to sound too boastful about our skills, talents, and accomplishments. But wait! If you donât, who will? The job market is a competitive place and there are plenty of other candidates who are ready to play. Remember, you are essentially selling yourself when applying for any jobâ"so donât be afraid to stand out. If you want to succeed and go far, the first step is to provide an appealing written representation of your employability. Writing a cover letter is hard work, but the writers at Homework Help Canada can help get you where you want to go. A well written cover letter crafted by our talented writers will help you in your search for a new full-time or part-time job; if the job search is stressing you out, get in touch with us and let us offer you some relief on the writing side. References: Harris, Peter. (2015, May 5). How to write a resume for a high-paying job (with sample). Retrieved August 20, 2015, from
Friday, May 22, 2020
Essay about Getting to know a few Differential Private...
1.2. Differential Privacy to the rescue. Privacy is a major problem these days. Cheaper memory has led to immense amount of data continuously being accumulated in various databases across the world, from universities, companies to patient records, content and link graphs of social net-works, mobility traces in cellular networks, book and movie ratings, etc.ââ¬âand there are many socially valuable uses to which it can potentially be put. But, as Netflix and others have discovered, even when data collectors try to protect the privacy of their customers by releasing anonymized or aggregated data, this data often reveals much more than intended, especially when it is combined with other data sources. This calls for the need to immediatelyâ⬠¦show more contentâ⬠¦Such a method is highly applicative for a wide variety of applications, be it Netflix or Twitter data to be analyzed by a Data Scientist. An adversarial querier could not, for instance, obtain an accurate answer to the query ââ¬Å"Has John followed Mark?â⬠because the cost of such a query would exceed any reasonable privacy budget. Even though everything seems fine till now, the adversary can still attack the userââ¬â¢s data. This is because we have assumed that all that the adversary can notice is the output of the query. However, the adversary can also notice the time taken for the system to reply to the query. Such observations can be exploited to mount a covert-channel attack. To continue with our earlier example, the adversary might run a query that always re-turns zero as its result but that takes one hour to complete if John Doe follows Mark and less than a second otherwise. Both Airavat and PINQ would consider such a system to be secure since the output is differentially private. However, the adversary can still learn with perfect certainty whether John follows Markââ¬âa blatant violation of differential privacy. Fortunately, the userââ¬â¢s access to the database only via queries leads to channels like power consumption [9] and electromagnetic radiation [5, 8] being ruled out, henceforth, leaving the adversary with just two channels: the privacy budget and the query completion time. TheseShow MoreRelatedEssay on Centers for Medicare and Medicaid Services and Reimbursement1324 Words à |à 6 Pagesconsolidate, and take some measures. I would like to discuss some issues and steps APNs must take regarding reimbursement as followed. First, why do APNs not receive equal reimbursement? The Medicare Payment Advisory Commission examined the payment differentials between the clinicians and physicians. Since the nature of billing codes is imprecise, the Center for Medicare and Medicaid Services was not able to distinguish the different categories of clinicians who provide similar services. They have thisRead MoreThe best teaching aid is a piece of chalk1458 Words à |à 6 Pagesis likely to cause bafflement to teachers. ââ¬Å"What else?â⬠would be their common response. Today, however, teaching aids abound. From a simple letter set painstakingly cut out by a devoted teacher, through electronic projection equipment, DVD sound systems, televisions and computers, to the latest interactive whiteboard, they introduce a wealth of variety and differing impact to todayââ¬â¢s classroom. Any discussion of this statement will therefore be remiss if I do not introduce and examine some availableRead MoreThe Ethical Codes Of Healthcare Professions1797 Words à |à 8 PagesAccording to Stephen Resnick, exploitation can be defined as ââ¬Å"Taking unfair or unjust advantage of another person for oneââ¬â¢s benefit or advantage without compensation or benefit to that other person.â⬠Pre-existing unequal relationships and power differential often instigate the likelihood of exploitation. â⬠¢ For instance, on March 9th, 2012, Rebecca Lean Smith, 39, returned to El Dorado County from her Louisiana home and negotiated a plea with California s attorney general over her role leading upRead MoreOffer a Critique of What John Rawls Meant by ââ¬ËFair Equality of Opportunityââ¬â¢2169 Words à |à 9 Pagesis when justice is being done and equality prevails. 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The evidence indicates that outright auditRead MoreStandardized Testing Should Not Be Applied For College2033 Words à |à 9 Pagest matter. Put some time into getting ready because they will have an impact on the admissions decisionâ⬠! With looking at standardized test score colleges can not see how well rounded the student is so they must look at other aspects. Another major area that is critical to college applications is an individualââ¬â¢s grade point average (G.P.A.). A G.P.A. is number representing an average of the accumulated grades an individual acquires over time. A G.P.A letââ¬â¢s colleges know that the student was or wasRead MoreEssay on Hidden Holidays3562 Words à |à 15 Pages 1. Introduction Hidden Holidays is a small travel company providing holidays villas in Florence and throughout Tuscany, Italy. The company is based in London but has a pan-European network of ten agents who match private holiday holiday accommodation with tourists throughout Europe. These agents are often former, holiday makers to the region. They work from home and contact the office in London via telephone and fax machine messages. Hidden Holidays does not makeRead MoreWhite Collar Crime: The Effects and Punishments5087 Words à |à 21 Pagesterm at the fourth annual meeting of the Sociological Association. At this meeting he explained who this type of criminal is and what the criminal does for a living. Sutherland developed a theory to try and fit this type of criminal. The theory is differential association. There are four different pieces of evidence to understand the theory. White collar crime ranges from Embezzlement to Mortgage Fraud. This paper will explain several incidents which are inv olved with white collar crime and how it hurtsRead MoreEssay about The Dangers of Social Media Correlating to Privacy3105 Words à |à 13 PagesPrivacy Privacy is ââ¬Å"the state of being free from intrusion or disturbance in oneââ¬â¢s private life or affairsâ⬠, stated by Dictionary.com. Now if we look at this definition more closely, we could see that the subject should have control over their belongings. This definition states that the person is free from disturbance from others in their space or belongings. I donââ¬â¢t see how this could be true for the online networking system, because once you put something online, in the internet space, it is in a space
Sunday, May 10, 2020
The Biggest Myth About Prejudice Against Females Essay Samples Exposed
The Biggest Myth About Prejudice Against Females Essay Samples Exposed What Does Prejudice Against Females Essay Samples Mean? Although women are highly educated the pay gap has ever been high between the women and men. As seen from the aforementioned, there's evidence that people's mind-set doesn't change easily. Prejudice is understood to be the unjustified negative attitudes that some individuals hold against others of a specific group of individuals. In many cases, people that have a prejudice against another group will go out of their way to generate life harder for those people. 1 fact that everybody can agree on, no matter where they live on the planet, is that folks are different. White folks cannot dance. Sometimes it's hard for folks to observe these stereotypes unless pointing them out by talking to family and friends. People today become tired of being criticized all of the moment. In this manner, Austen demonstrates that attitudes to marriage can be quite different. A behavioural prejudice essay could tell people that there might be some prejudices which might not be acted out and hence it's regarded as an attitude. We frequently find prejudice and discrimination go together. The quick conversation can't decrease the prejudice. It isn't hard to find that with are actions and sayings we are attempting to kill emotions and thoughts! In Pride and Prejudice Jane Austen shows the reader that the very first impression isn't always correct, in reality, it's deceptive. This feeling might result in a reaction that could incorporate prejudice and discrimination. Frequently, there's evidence an individual's prejudice isn't right, but they ignore it. Women are often still the topic of bigotry and hate just because of their gender. Men can also suffer from discrimination. They are already afraid to have a look at a beautiful woman it could be judged as sexual harassment. Men should not suffer in silence once it comes to sexism. The standard roles and duties, which the females are expected to perform is also reason for the high amount of domination from they must face away from their husbands. If she's not able to fulfil her responsibilities due to her pregnancy she is believed to be a disabled worker by her s ubordinates. Daniels claimed he was harassed by fellow employees due to his race. It's considered an offence equal to racial discrimination, and a few countries adopt very harsh punishments for people who are charged with these kinds of difficulties. It's possible to find this goal, if only 3 conditions are satisfied. Although the majority of the world have moved past gender discrimination, but there continue to be countries practicing gender discrimination, and it's not one or two, but large enough to make an effect on the world in general. Racial Discrimination This sort of discrimination is directed at individuals or groups due to their race or ethnicity. The Battle Over Prejudice Against Females Essay Samples and How to Win It Men and women are available in all sizes, shapes, and colours. Stereotypes can be negative or positive, but they're rarely communicating accurate info about other folks. Education is regarded as the best technique for self-improvement and financial independence. Prejudice against Females Essay Samples Ideas Institutional discrim ination happens during one-on-one encounters once a person goes about his day-to-day life. Considering all the differences on earth rather than embracing those differences and learning from different men and women, prejudices are commonplace. By applying the eyes of a youngster, the racial prejudice that's represented inside this novel is not as provocative and toned down to match the innocence of a youngster's mind. Citations and extracts from several sources have to be formatted properly. Provide citations for all of the sources you use. Having stood the test of many epochs, the novel is still one of the very best in the world literature. This isn't an instance of the work generated by our Essay Writing Service. Life, Death, and Prejudice Against Females Essay Samples She clearly understood the value of a financial situation, but it isn't the main point for her. In addition, by emphasising these jail terms, he's invited the audience to realize that there'll be a slow tr ansition to justice in Mississippi. There are lots of reasons for which paying a female worker under a male worker is thought to be a discriminatory practice from a moral viewpoint. In this instance, Mr Collins. Among the panelists with racist ideologies is an illustration of prejudicial victimization. In earlier times gender discrimination proved to be a frequent occurrence across the world. The racism is broken up into few types. Scientific racism insists that all folks may be characterized by certain bodily traits. What You Need to Do About Prejudice Against Females Essay Samples Beginning in the Next 15 Minutes In the last few decades, the issue related to gender discrimination has gotten very severe. In this instance, tolerance wasn't used and innocent people suffered. In the us, black folks have been victims of various kinds of discrimination. However, this isn't only a problem in unprogressive nations.
Wednesday, May 6, 2020
Working Adolescents Free Essays
Whether an adolescent should be working during their high school years or not, one cannot be absolute with hiss answer.à These question can be best answered when one looks at its advantages and disadvantages, their workplace, nature of the job and number of hours should alsoà be considered. I do believe there is a place for it provided that the workplace is owned by the family. We will write a custom essay sample on Working Adolescents or any similar topic only for you Order Now à Exposing an adolescent to the nature of their own business, which in the later he has no choice but to be part of it, is of great advantage.à This is considering that in the early age he will be learning the mechanics, and system of the business which will prepare him for the future. Though the problem would be, being a family member the tendency to over familiarity is unavoidable, and the person can be a subject to exploitation in terms of time, and may also be to mental harassment, through insults and words of impatience, just like in the outside workplace whenà in the midst, crisis will arise employers tend to hurl insults.à Tendency to abuses is really existing elsewhere! Inevitably the high school years are crucial to the social and emotional development of both boys and girls.à Although there are benefits one can earn when working while adolescent, such that it provides lessons about responsibility, punctuality, to some degree independence, interacting with the public, and the list goes on, and for sure finances. (Moskowitz, 2000). However, Fineran (2002) reported that a study was conducted and results described adolescents experiencing with sexual harassment while working part time and attending high school.à In a sample of 712 high school students, 25% of the 372 students while working part-time report experiencing sexual harassment. And effects of sexual harassment during a first job showed may also negatively affect a childââ¬â¢s self-esteem, and self confidence, anger, irritability, social isolation helplessness and anxiety, depression, tension, and nervousness (Fitgerald,1933), Gutek and Koss(1993) proposed a posttraumatic stress disorder model for understanding the mental health consequences of sexual harassment. (Moskowitz, 2000) also added that it would also affect the adolescentââ¬â¢s identity formation in addition to placing him or her in physical danger of assault and trauma.à Results revealed that there are difference in the experience of sexual harassment by gender, work relation, and emotional reaction. Fineran (2002) furthermore reported that girls are significantly more upset and threatened by the sexual harassment they experienced at work than boys. The same report mentioned that mental harassment also occurs when they are insulted by their supervisors, coworkers and customers.à Looking to these, both are detrimental to the development of adolescence to adulthood.à A negative impact has somehow embedded in them. In an article entitled Adolescent in the Workplace, stated that indeed working has been shown to be associated with both positive and negative consequences for adolescents. Working may increase responsibility, self-esteem, and independence and may help children and adolescents learn valuable work skills. Employment that is limited in intensity (usually defined as 20 hours or less per week) during high school years has been found to promote postsecondary educational attainment. Many studies show positive links between working during high school and subsequent vocational outcomes, including less unemployment, a longer duration of employment after completing schooling, and higher earnings. However, high-intensity work (usually defined as more than 20 hours per week) is associated with unhealthy and problem behaviors, including substance abuse and minor deviance, insufficient sleep and exercise, and limited time spent with families. Furthermore, children and adolescents may be exposed to many work-related hazards that can result in injury, illness, or death. Their inexperience, as well as physical, cognitive, and emotional developmental characteristics, may also play a part in the risk of injury faced by young workers. Injury may also result from a physical mismatch between the size of the child or adolescent and the task: for example, machinery that was designed for adult males may be too large or heavy for children or adolescents to handle safely. According to NIOSH the most common types of injuries and illness are sprains and strains, cuts and lacerations, contusions and abrasions, heat burns, and fractures and dislocations.à R. Belville, S. H. Pollack, J. H. Godbold and P. J. Landrigan concluded that occupational injuries are substantial and under recognized contributor to the continuing epidemic of injury among adolescent. Besides Rosalie Bakken in her article entitles Ups and Downs mentioned that although it is widely believed that having a job builds character in young people, it can also provide opportunities for youth to learn specific job skills, save money for college, develop trusting and healthy relationships with non-family adults, and experience feelings of reward and intellectual stimulation. But the same studies showed that employment does not necessarily lead to healthy social or moral development. This is especially true when a young personââ¬â¢s very first experience in the work force involves stress, long hours, and menial tasks. Most jobs held by youth do not provide many opportunities for youth to think creatively or to solve challenging problems or make independent decisions. In addition, research has shown that earning an independent income does not mean that youth are learning to use their money wisely. In fact, their personal income may provide working adolescents with greater opportunities to purchase alcohol, drugs or cigarettes. Rosalie Bakken also cited that a notable characteristic of working adolescents is that they move in and out of the labor market, changing jobs and work schedules frequently, in response to changes in employersââ¬â¢ needs, labor market conditions, and circumstances in their own lives. This to some degree makes them very unstable and unstructured, leading to very unorganized life, without routines in schedule and activities.à Looking for another job, to cope with loses financially, has added to the tensions and pressures in schools and even in this area of his life -working as adolescent. Considering that an adolescent needs to do good in his studies and at the same time be working for several hours, in addition to his load in school means a lot of pressure to an adolescent. And may therefore distract him from his studies and his focus will be divided, which is to the advantage both to him, and the teacher who will be relating with him in all his academic requirements. In fact it was also shown that a high level of work during adolescence has been found to be associated with decreased eventual educational attainment. Although on sessions where the teachers discuss on social awareness, the teacher may enjoy interacting with him, considering his exposure in the workplace. For the parents, the fact that they are relieve in some sense in supporting to their adolescence, their sense of dignity as a provider also diminishes, and since the child spends time outside in school added with the time in work lessen their time together.à This is of very great disadvantage, the fact that the child should be learning and be influenced a lot from their parents at this age, instead they got it from the workplace. However, in the midst of working institutions so much abuses and harassment are going on, which I would say not an advantage for an adolescent to work. If working is the only solution that an adolescent can enter and sustain his way to high school, then I believe he should.à Though it really means a lot of difficulties.à When he dares to, as much as possible things should be defined and determine carefully. The determining factors are the type of job an adolescent takes, and the number of hours worked. The job should be meaningful to the teen in some genuine way, and it should not interfere with time needed for schoolwork or family interaction. Teenagersââ¬â¢ needs for adequate nutrition, exercise and rest should not be compromised by a job. (Bakken, 2001) Teens should look for a job that will be challenging, interesting, and that will provide them with opportunities to use the skills they have and learn new ones. The job atmosphere should be supervised by an adult and should allow the adolescent to come into frequent contact with healthy adult role models. (Mortimer et al, 1996) Finally, working adolescents should not also relate with their parents their work experiences, allow the to monitor any changes in their grades, attitudes, or behaviors. BIBLIOGRAPHY Bakken, Rebecca, Ph.D. 2001. Adolescents at Work. From theà Ups and Downs of Adolescents: A Newsletter about and for Young People, Parents and Concerned Adults. http://www.ianr.unl.edu/ianr/fcs/upsdowns/upsaug01.htm How to cite Working Adolescents, Papers
Wednesday, April 29, 2020
Walt-Mart Ethical Culture Essay Sample free essay sample
Todaies as we live in a planetary economic system. the common cognition of ethical civilization provides identifying characteristic and values for organisational members to acknowledge and go informed. Cultures can be distinguished by artefacts. values. and basic traditions. On the other manus net income maximization harmonizing to ( Jensen 2002: 240 ) . Firm taking inputs out of the economic system and seting its end product of goods and services back into the economic system increases aggregate public assistance if the monetary values at which it sells the goods more than cover the costs it incurs in buying the inputs. As the one of the worldââ¬â¢s largest corporation. Wal-Mart Stores. Inc. has had its just portion of examination in the yesteryear and today from many groups which optimism to alter the companyââ¬â¢s policies in order to better function the greater good of the community. The intent of this paper is to analyse Wal-Mart ethical civilization. We will write a custom essay sample on Walt-Mart Ethical Culture Essay Sample or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page comparison and contrast on the alterations that they made. Besides elaborate on consumer relationship as it relate to their civilization. In add-on. how Wal-Mart labour force impacted its corporate net incomes overall. so our community. Wal-Mart ethical civilization and corporate net incomes will ever associate to each other whether it positive or negative base on what is most of import to them. Furthermore ; the negative impact of Wal-Mart will neer travel off wholly because of their size entirely and differences of public sentiments. As I conclude my determination. unless consumers are all of a sudden careless about salvaging more than ethical civilization and the right manner to maximise net incomes. concern and inquiries about Wal-Mart are inevitable and will ever go on every bit long as the company exists. IntroductionFor the bulk of people in the United State Wal-Mart is one of the most often visited finishs to shop for food markets and other comfortss. Wal-Mart has become a one halt store where people can perchance purchase about everything they need. Harmonizing to papers posted on ( PBS. ORG. 2004 ) . in 2004 one hundred million Americans store at Wal-Mart shops hebdomadal. I can merely conceive of today that figure since so have been increase due to more enlargement of the company. They have grown from food markets store to supper centre where everything including cosmetics is under one roof. The original thought of Wal-Mart supplying goods and supplies for less money started with Sam Walton back in the early 60ââ¬â¢s. In the late fortiess. when Sam Walton was franchising a Ben Franklinââ¬â¢s assortment shop in Newport. Ark. . he had a simple but momentous thought. Like any retail merchant. Walton was ever looking for trades from providers. Typically. though. a retail mercha nt who managed to acquire a deal from a jobber would go forth his shop monetary values unchanged and pocket the excess money. Walton. by contrast. realized he could make better by go throughing on the nest eggs to his clients and gaining his net incomes through volume ( Frank. 2006 ) . Mentions: PBS. ORG. ( 2004. 11 16 ) . Retrieved 02 17. 2013. from Frontline: hypertext transfer protocol: //www. phosphate buffer solution. org/wgbh/pages/frontline/shows/walmart/secrets/stats. hypertext markup language Frank. T. ( 2006. 04 ) . Reclaim Democracy. Retrieved 02 15. 2013. from reclaimdemocracy. org: hypertext transfer protocol: //reclaimdemocracy. org/brief-history-of-walmart/
Friday, March 20, 2020
Free Cover Letter Sample for Marketing Job
Free Cover Letter Sample for Marketing Job SAT / ACT Prep Online Guides and Tips The writer of this cover letter works in marketing, so hopefully he's able to market for himself with a strong cover letter! As you'll see below, the applicantuses a list format to presenthis professional skills and draw direct connections with the job's requirements. Read on to see how the applicant describeshis experiences,and then continue on to an analysis of what this sample cover letter does well. Cover Letter Sample for Marketing Manager Position Bran Starkman5 Tree LaneSnowtown, CO 80001 May 1, 2016 Cecily LannisterDirector of MarketingKing Co.10 Landing St.Sunnyvale, CA 94085 Dear Ms. Lannister, Iââ¬â¢m writing to express my strong interest in joining King Co.ââ¬â¢s team as Marketing Manager, an opportunity I discovered on Monster.com. King Co. takes such an innovative approach to itsmarketing, and I would love to contribute toits progressive vision.With my five years of experience in marketing management, I havethe skills and knowledge to excel in this role. Please allow me to highlight my qualifications as they related to your stated requirements. Your Requirements My Experience Marketing degree, 3 years exp. Obtained my BA in Marketing Communication in 20 and have three years of experience as an SEO Content Marketing Manager Skilled with content strategy development and implementation Developed and executed SEO strategy that achieved top 3 rankings on Google for key product search terms; led team that expanded unique visitors from 10k/month to 2 million/month in one year Social media guru Maintained editorial calendar across social media platforms; oversaw 30% increase in Facebook and Twitter shares; synchronized social media posts with content publication Professional, personable, and passionate 3 years of successful content team management while maintaining strong interpersonal relationships; devoted to fostering open communication and supporting growth of team members Iââ¬â¢ve attached my resume to flesh out my professional background as Marketing Manager, along with two letters of recommendation. Iââ¬â¢m very excited about this opportunity with King Co. and look forward to speaking with you soon. Please donââ¬â¢t hesitate to contact me at 508-508-5080 or bran.starkman@gmail.com. Thank you for your consideration. Sincerely, Bran Starkman Bran Starkman508-508-5080 bran.starkman@gmail.com Bran says he's skilled with content; did this skill come through in his cover letter? Marketing Manager Cover Letter: The Breakdown Bran took a bullet point approach to his cover letter, using a list to match the positionââ¬â¢s stated requirements with his own qualifications in a form thatââ¬â¢s sometimes referred to as an executive briefing. Visually, this format makes his letter easy to read and understand. He showed an understanding of the position by explicitly listing its requirements, and he provided specific examples of his professional accomplishments with data. Bran's measured approach seems to work well for the position of marketing manager, which also requires a high degree of organization and the use of metrics to measure impact. Branââ¬â¢s cover letter hits the four key features described in our cover letter guide - itââ¬â¢s customized to the job at hand, it uses specific examples, it communicates enthusiasm, and itââ¬â¢s highly readable. Bran includes his and the hiring manager's contact information at the top, so presumably he's sending his cover letter as a hard copy or Word document attachment. Hopefully, his cover letterwill land Bran an interview with King Co. Before you check out more cover letter samples, consider the followingimportant note on format. A Note on Format Before addressing the hiring manager, Bran provided a header with his name and contact information at the top of his cover letter. He also added the date and contact details of Ms. Lannister. This kind of formatting is traditional for cover letters, and it still works well if you're sending your letter by hard copy or as a Word attachment. Many jobs, though, expect you to paste your cover letter in the body of an email or in a text box on their application portal. If you're sending your letter this way, then you can usually leave off these headers. They're more applicable if you can format your letter with a certain look. If you're going the plain text body of email or text box approach, then you can just start right in with the salutation. As you finalize the look of your cover letter, consider how you're sending it, along with any application instructions. Then let that method guide your cover letter's final look! What's Next? Are you ready to read another cover letter? Check out this sample cover letter for the job of Editorial Assistant with a publishing company. Would you like tolearn more about cover letters? Our full guide has great tips on writing cover letters, along with five more samples! Are you wondering how to structure your letter? Our cover letter template guides you through the writing process, step by step.
Wednesday, March 4, 2020
How to Do a Flame Test for Qualitative Analysis
How to Do a Flame Test for Qualitative Analysis The flame test is used to visually determine the identity of an unknown metal or metalloid ion based on the characteristic color the salt turns the flame of a Bunsen burner. The heat of the flame excites the electrons of the metals ions, causing them to emit visible light. Every element has a signature emission spectrum that can be used to differentiate between one element and another. How to Do the Flame Test Classic Wire Loop MethodFirst, you need a clean wire loop. Platinum or nickel-chromium loops are most common. They may be cleaned by dipping in hydrochloric or nitric acid, followed by rinsing with distilled or deionized water. Test the cleanliness of the loop by inserting it into a gas flame. If a burst of color is produced, the loop is not sufficiently clean. The loop must be cleaned between tests. The clean loop is dipped in either a powder or solution of an ionic (metal) salt. The loop with sample is placed in the clear or blue part of the flame and the resulting color is observed. Wooden Splint or Cotton Swab MethodWooden splints or cotton swabs offer an inexpensive alternative to wire loops. To use wooden splints, soak them overnight in distilled water. Pour out the water and rinse the splints with clean water, being careful to avoid contaminating the water with sodium (as from sweat on your hands). Take a damp splint or cotton swab that has been moistened in water, dip it in the sample to be tested, and wave the splint or swab through the flame. Do not hold the sample in the flame as this would cause the splint or swab to ignite. Use a new splint or swab for each test. How to Interpret Flame Test Results The sample is identified by comparing the observed flame color against known values from a table or chart. RedCarmine to Magenta: Lithium compounds. Masked by barium or sodium.Scarlet or Crimson: Strontium compounds. Masked by barium.Red: Rubidium (unfiltered flame)Yellow-Red: Calcium compounds. Masked by barium. YellowGold: IronIntense Yellow: Sodium compounds, even in trace amounts. A yellow flame is not indicative of sodium unless it persists and is not intensified by anà addition of 1% NaCl to the dry compound. WhiteBright White: MagnesiumWhite-Green: Zinc GreenEmerald: Copper compounds, other than halides. Thallium.Bright Green: BoronBlue-Green: Phosphates, when moistened with H2SO4 or B2O3.Faint Green: Antimony and NH4 compounds.Yellow-Green: Barium, manganese(II), molybdenum. BlueAzure: Lead, selenium, bismuth, cesium, copper(I), CuCl2 and other copper compounds moistened with hydrochloric acid, indium, lead.Light Blue: Arsenic and some of its compounds.Greenish Blue: CuBr2, antimony PurpleViolet: Potassium compounds other than borates, phosphates, and silicates. Masked by sodium or lithium.Lilac to Purple-Red: Potassium, rubidium, and/or cesium in the presence of sodium when viewed through a blue glass. Limitations of the Flame Test The test cannot detect low concentrations of most ions.The brightness of the signal varies from one sample to another. For example, the yellow emission from sodium is much brighter than the red emission from the same amount of lithium.Impurities or contaminants affect the test results. Sodium, in particular, is present in most compounds and will color the flame. Sometimes a blue glass is used to filter out the yellow of sodium.The test cannot differentiate between all elements. Several metals produce the same flame color. Some compounds do not change the color of the flame at all. Because of the limitation, the flame test might be used to rule out the identity of an element in a sample, rather than definitively identify it. Other analytical procedures should be conducted in addition to this test. Flame Test Colors This table lists the expected colors for elements in the flame test. Obviously, the names of the colors are subjective, so the best way to learn to recognize close-colored elements is to test known solutions so you know what to expect. Symbol Element Color As Arsenic Blue B Boron Bright green Ba Barium Pale/Yellowish Green Ca Calcium Orange to red Cs Cesium Blue Cu(I Copper(I) Blue Cu(II) Copper(II) non-halide Green Cu(II) Copper(II) halide Blue-green Fe Iron Gold In Indium Blue K Potassium Lilac to red Li Lithium Magenta to carmine Mg Magnesium Bright white Mn(II) Manganese(II) Yellowish green Mo Molybdenum Yellowish green Na Sodium Intense yellow P Phosphorus Pale bluish green Pb Lead Blue Rb Rubidium Red to purple-red Sb Antimony Pale green Se Selenium Azure blue Sr Strontium Crimson Te Tellurium Pale green Tl Thallium Pure green Zn Zinc Bluish green to whitish green Source Langes Handbook of Chemistry, 8th Edition, Handbook Publishers Inc., 1952.
Sunday, February 16, 2020
The Role of Geoprofiling in the Analysis of Crime Series Annotated Bibliography
The Role of Geoprofiling in the Analysis of Crime Series - Annotated Bibliography Example In this book Boba has tried to explain the use of crime mapping in crime analysis. It offers a great deal of information regarding the integration of geospatial techniques into criminal investigations. Further, this nook offers methods for using different crime mapping methods for analyzing criminal activities. Crime mapping case studies: Practice and Research is written by Chainey, S. The book offers various methodologies used for crime mapping. Further it offers an approach to bring crime mapping into practice, along with new directions in this field of study. This book elaborates the present trends in crime mapping research. The book offers numerous case studies that help the readers in understanding the basics of crime mapping and its use in the real life. Chainey and Ratcliff has combined the theoretical principles, analytical techniques from geographic information system, methods for processing data sets, measures for sharing information, problem solving, and lots of other related topics. This book offers case studies and real life examples to elaborate and explain the integration geographic information system and crime mapping. This book is useful for the students as well as for the professionals. It can be used as a reference guide for solving problems associated with crime mapping. The growth of science and technology has made information security a great concer. Organizations need to obtain fool proof information security systems in order to prevent it from being lost or being accessed by unauthorized user. Authentication and retrieval of information requires efficient system that ease out the access to the information sources for the authorized users, yet it prevents interruption from third party. Companies spend a great deal of their assets in preserving their information, because loosing information is equal to the death of the company. This is an interview/ article by Marc Goodman,
Monday, February 3, 2020
Children and IQ Testing Coursework Example | Topics and Well Written Essays - 250 words
Children and IQ Testing - Coursework Example When developing childrenââ¬â¢s cognitive and physical features are very challenging tasks. Their learning abilities depend on the teachersââ¬â¢ influence, environment and individual interests. Therefore, it is vital for teachers to identify their studentsââ¬â¢ strengths and put more emphasis on their weak areas. In cases where some students perform well than others, it is the duty of teachers to arrange for private tutorials for weak students. This motivates them greatly and helps them in clarifying the areas they did not understand in class. In my view, these gifted students should not be placed in special schools rather be mixed. That way, they can use their skills to help the weak ones realize their goals (Rosenberg et al., 2007, p. 415). In addition, gifted students have a high degree of empathy for other students. Therefore, through this they can assist their fellow students in conducting their assignments and meeting the teachersââ¬â¢ objectives. Finally, most public schools have not been able to meet the needs of extremely gifted students. This is because they lack adequate learning resources to nurture students of such behavior. Therefore,more funds should be channeled to public schools so that gifted students can realize their full
Saturday, January 25, 2020
Whole Exome Sequencing in Inherited Endocrine Disorders
Whole Exome Sequencing in Inherited Endocrine Disorders Background Molecular diagnosis is important in the management of various paediatric endocrine disorders including disorders of growth, metabolism, bone, hypoglycaemia and sexual development. Traditional PCR-based Sanger sequencing is the mainstay format for molecular testing in paediatric cases. However, the large number of gene defects associated with the various endocrine disorders renders gene-by-gene testing increasingly expensive and unattractive. The large number of potentially relevant genes makes it challenging for hospital molecular diagnostic laboratories to offer gene-based testing of all candidates. Given the high costs associated with single-gene tests, the selection of candidates for single-gene sequencing tends to be sequential rather than inclusive and parallel. In practice, different genes may be outsourced to different clinical or in some cases academic research laboratories which adds to the complexity. Using new high-throughput sequencing technologies, whole genomes, whole e xomes or candidate-gene panels (targeted gene sequencing) can now be cost-effectively sequenced for endocrine patients. In the near future, protocols involving next-generation sequencing would probably be considered as an appropriate component of routine clinical diagnosis for relevant patients. Defects of pituitary hormones lead to abnormalities in growth (e.g., short stature), sexual development, fertility, stress response and other metabolic processes. A number of genes coding for transcription factors have been identified, mutations in which cause medical disorders in humans associated with pituitary deficiencies [1-2]. Some of these factors, such as PROP1, TPIT, POU1F1, LHX3 and LHX4, play roles in the normal embryological development of the anterior pituitary. Mutations in these genes can lead to multiple pituitary hormone deficiencies and/or syndromic hypopituitarism [3]. The transcription factors such as HESX1, OTX2, SHH, SOX2 and SOX3 are involved in midline development. Mutations in these can cause septo-optic dysplasia or holoprosencephaly, both of which may include pituitary hormone deficiencies [4]. Other genes encode the precursors to pituitary hormones (growth hormone, ACTH [through processing of POMC], gonadotropic-luteinizing hormone and follicle-stimulating hormone, and thyroid-stimulating hormone). Mutations in these genes lead to phenotypes characteristic of individual hormone deficiency. The pituitary secretory cells themselves respond to signals originating in the hypothalamus, some of which are also peptide hormones with specific receptors expressed on the responding cells; mutations in these genes or their cognate receptors can also cause combined or specific pituitary deficiencies [1]. However, many cases of congenital hypopituitarism still remain unexplained and most are presumably due to other causes, either mutations in other deve lopmental genes or epigenetic influences during embryogenesis. Short stature is a common presentation to the paediatric endocrinology clinics. However, no cause is identified in a large proportion of patients who are classified as having idiopathic short stature [5, 6, 7]. It is estimated that the underlying cause for short stature remains unknown in approximately 80% of patients [8]. In a large-scale pooled Next-Generation Sequencing study to identify genetic causes of short stature, 4928 genetic variants in 1077 genes were present in patients but not in control subjects [9]. Large-scale sequencing efforts have the potential to rapidly identify genetic aetiologies of short stature. In another study, seeking to identify known and genetic causes of short stature by conducting whole exome sequencing of the patients with severe short stature and their family members, genetic cause of short stature was found in 5 out of the 14 recruited patients [10]. Rare genetic defects in the GH/IGF-1 axis have been found to cause short stature. A higher frequenc y of rare CNVs (common number variants) has been reported in patients with short stature [8, 11]. A recent study to define genetic characterisation of a cohort of children clinically labelled as Growth Hormone or IGF1 insensitive found that whole exome sequencing contributed to the diagnosis of children with suspected growth hormone and IGF1 insensitivity, particularly in the Growth hormone insensitive subjects with low serum IGF1 SDS and height SDS [12]. It may be now possible to identify likely genetic causes of short stature by implementing genomic investigative techniques like whole exome sequencing in many of these children who have unknown reasons for their poor linear growth. Congenital Hyperinsulinism (CHI) is the most common cause of persistent and recurrent hypoglycaemia in infancy [13]. It is the result of unregulated insulin secretion from the pancreatic à ²-cells leading to severe hypoglycaemia [13, 14]. This condition has been reported in nearly all major ethnic groups and affects at least 1/50,000 children of European descent [14]. CHI is caused by genetic defects in key genes regulating insulin secretion. The genetic basis of CHI involves mutations in nine different genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A, HNF1A and UCP2), which regulate insulin secretion from the pancreatic à ²-cells [14,15]. The most common molecular cause of CHI is the dysfunction of the pancreatic KATP channel encoded by the sulfonylurea receptor gene (ABCC8) and the inward rectifying potassium channel gene (KCNJ11) [14,15]. CHI can also be secondary to risk factors like birth asphyxia, intra-uterine growth retardation, Rh isoimmunisation and maternal diabetes mellitus or associated with various developmental syndromes [16]. Histologically, CHI can be associated either with diffuse insulin secretion or with focal adenomatous hyperplasia. Positron emission tomography scan using Fluorine-18 L-3, 4-dihydroxyphenylalanine (18-fluoro DOPA-TC-PET-scan) has been used to distinguish focal from diffuse forms. Medical treatments of CHI include diazoxide (KATP channel activator), somatostatin analogue (octreotide) injections, and appropriate diet. The surgical treatment with subtotal pancreatectomy is required in diffuse CHI when medical treatment and dietary therapies are ineffective, whereas focal CHI can be cured with resection of the focal area of adenomatous hyperplasia [14, 15, 16]. Recently, mammalian target of rapamycin (mTOR) inhibitor sirolimus has been used in treatment of persistent severe CHI not amena ble to medical therapies [18]. CHI has been described as an associated finding in various syndromes like Beckwith-Wiedemann, Kabuki, Trisomy 13, Mosaic Turner, Sotos, Usher, Timothy, Costello, Central Hypoventilation syndrome and Leprechaunism (Insulin Resistance Syndrome) [17]. However, in many patients, with clinically defined syndromic features and with hypoglycaemia, no identifiable genetic cause contributing to hyperinsulinism is found. In a large series of 300 patients, genetic diagnosis was made only in 45.3% of the patients and mutations in ABCC8 were the commonest identifiable cause [19]. The vast majority of patients with Diazoxide-responsive CHI (77.6%) had no identifiable mutations, suggesting other genetic mechanisms [19]. Molecular diagnosis can be very important for clinicians to manage the patients more effectively and to counsel parents on the prognosis and disease recurrence. Whole Exome sequencing can be advantageous in these groups of patients to identify the mol ecular defects and to assess the coding variants that may be pathogenic in these patients [20]. Aims To identify novel genetic causes of rare inherited endocrine disorders in children with a focus on congenital hyperinsulinism, short stature of unknown etiology and IGF1 abnormalities by using whole exome sequencing. Experimental Design and Methods Patient Recruitment Patients with a diagnosis of CHI referred to Alder Hey Childrenââ¬â¢s Hospital, which is a national referral centre for CHI, will be recruited into the study. A written informed parental consent will be obtained. These patients will be biochemically confirmed as CHI using the following criteria: Blood glucose concentration of less than 3.0 mmol/l with detectable insulin and/or C-peptide Glucose requirement > 8mg/kg/min Low levels of ketones and fatty acids during the episode of hypoglycaemia Clinical and biochemical data will be collated from referral letter or by case note review. Patients with a secondary cause of CHI such as perinatal asphyxia, intra-uterine growth restriction, Rhesus isoimmunisation, infants of diabetic mothers and infants with Beckwith Wiedemann syndrome will be excluded from the study. Patients are considered to be unresponsive to medical treatment if recurrent hypoglycaemia episodes ( Patients attending the Paediatric Endocrinology clinic at Alder Hey Childrenââ¬â¢s Hospital with severe short stature (>3 SDS below mean) for age and sex in whom the standard clinical work up has not revealed a diagnosis for their short stature will be recruited into the study. Patients referred or evaluated for growth hormone insensitivity (growth failure, low serum IGF1 and normal/elevated serum GH) or IGF1 insensitivity (pre- and postnatal growth failure associated with relatively high IGF1 levels) will also be recruited into the study. A written parental informed consent will be obtained prior to the recruitment. Whole Exome Sequencing (WES) WES will be performed at the Centre for Genomic Research (CGR) based at the University of Liverpool. The test will be ordered after explaining the risks and benefits of testing to the patient and obtaining written informed consent. Each patient (and their parents or guardians) will be advised of the potential disclosure of conditions unrelated to the indication for testing that might warrant treatment or additional medical surveillance for the patient and possibly other family members. Peripheral-blood samples will be obtained to isolate DNA from the patient and both parents where possible. High-throughput sequencing will be performed using Illumina HiSeq2500. The genomic DNA samples from probands will be fragmented, ligated to Illumina multiplexing and amplified by means of a polymerase-chain-reaction assay with the use of primers with sequencing barcodes. Variants that were deemed clinically significant will be confirmed by means of Sanger sequencing. Parental samples, if available, will also be analysed by means of Sanger sequencing. Further functional analysis will be undertaken to establish the pathogenicity of the identified variant by utilising the in-house lab facilities at Institute of Child Health. Relevance of the proposed project Despite the advances in understanding the molecular pathogenesis, specific genetic determinants are not known in nearly 50% of patients with CHI and 80% of children with short stature. Whole exome sequencing in this group of patients will help to understand and identify the potential causative mutations in genes implicated in insulin regulation and growth. This will help the clinicians to provide optimal treatment and to counsel patients on disease progression and recurrence risk. Identification of novel genetic aetiology has the potential to identify novel therapeutic strategies for these patients. The applicant will spend time initially at Alder Hey Childrenââ¬â¢s Hospital to recruit patients and then at Cincinnati Childrenââ¬â¢s Hospital to learn the techniques of WES, bioinformatics and functional analysis. The applicant will then return to Alder Hey Childrenââ¬â¢s Hospital Institute of Child Health, University of Liverpool to complete the study and strengthen the local research expertise relevant to next generation sequencing.
Friday, January 17, 2020
Ethics Audit Question Essay
Board ââ¬â Does the board have a clear and concise plan of action to deal with problems that arise from regular assessment? This question is important when assessing an organizationââ¬â¢s ethical performance. This question will help the organization create a plan of action to deal with any problem that may arise. Staff- Are all staff members educated equally about how to advance in the organization? This question would help the organization make sure that they are treating all employees the same, as well as giving them all the same opportunities. The question would also aid in the assessment of the organizations ethical performance. Donors and Fundraisers- Does the organization give the donors the proper instructions or information on how to write their donations as tax write offs or deductions? In an ethical performance review, the organization will show that it cares about the donors, and is following government procedures. Clients/Customers- Is there a policy in place to ensure that all clients are given the same amount of time to be helped and processed? In an ethical review this shows that all clients are treated equally without prejudice or bias regardless of age, ethnicity, race, origin, or sex. Volunteers- Are all volunteers treated the same, and given equal opportunities for employment in the organization? It is important for the organization to show their volunteers that they are valued and important to the organization. Society- Is the organization doing everything it can, to meet the expectations of the public it serves? It is important for the organizations ethical committee to know that the organization is doing all that it can to serve the publicââ¬â¢s needs. The public will feel like they can trust the organization.
Thursday, January 9, 2020
The Human Resource ( Hr ) - 1655 Words
The human resource (HR) in an organization deals with the day to day operations of the human resources department. The HR department deals with business law, compensation, employee relations, benefits, medical and the like. HR focuses on whom the organization hires, whom the organization fires and remediation to employees who need discipline and retooling to continue their employment. The functions of the HR department in my organization include: recruiting and retaining talent, performance management and compensation, employee benefits, recruitment and staffing and employee rights and safety. In spite of the turbulent environment facing the healthcare industry today, my organization has however proven its effectiveness in performanceâ⬠¦show more contentâ⬠¦Recruiting and retaining talent has been noted as a top priority for participating best-practice companies. Benson noted that attracting and retaining top talent personnel ties in with the belief that ââ¬Å"getting the rig ht people on the bus is likely to lead to better employee performance and long-term business successâ⬠. Investing in training and organizational programs enhances employee skills and provide opportunities of future career growth to internal candidates. Leadership training is also required of newly hired and promoted supervisors and managers on topics such as performance management and how to handle employee relations matters at the department level. Mayhew and Media p 4 Employee benefits The HR department communicate effectively with employees and keep them informed of major issues and initiatives like sharing financial salary, and performance information to develop a high-trust organization with employees. They also provide employment security for employees who perform well so that they are not downsized because of economic downturns or strategic errors by senior management. With regards to compensation and benefits the HR functions include setting compensation structures and evaluating competitive pay practices. Mayew and
Wednesday, January 1, 2020
Decision Making An Integrated Structure Of Events
There are certain personality traits that team leaders require in order to assert influence and function properly in their role. As information and knowledge are disseminated throughout a team, the intellectual capacity of both the team and the organization is increased. Such a strategy is sometimes referred to as pyramiding or pyramid learning, meaning that knowledge is spread from one team member to another before eventually spreading throughout the entire team. Decision-making Decision making is an integrated structure of events that includes collecting, understanding, and exchanging information (). Pre-established measures and veto policies are vital when it comes to an organization developing strategies to aid in decision makingâ⬠¦show more contentâ⬠¦Team Motivation Employees that feel empowered by their leaders have greater job satisfaction, show commitment to the organization and generally have high performance are more creatively engaged. Motivation is the key to holding a team together. In many circumstances, motivation determines the amount of effort individuals are willing to put into their work. Therefore, it is important for you to ensure that your team is highly motivated in its work. Meyers Brigg indicator assist with this and furthermore can be linked into different motivation theories. By understanding and how MBTI are linked to motivation, helps to enhance the understanding the role in personality and particularly with the knowledge based personality processes. Individual can be either intrinsic or extrinsic motivated, however, knowing if your team members like to be motivated by rewards or by activities reflects back in a more productive and successful team. A lack of motivation in any team member can have a negative effect, not o nly reducing the team s effectiveness as a whole but also possibly leading to the demotivation of others. Key Leadership Theories There are three main leadership theories, behavioral, trait, and contingency theory. Behavioral Theories: The behavioral theories approach to an effective behavior leader. The study determines on the behavior attitude of the leader on encouraging the team towards the work environment. TheShow MoreRelatedHarvard Case Study: Ledina Lushko Essay1435 Words à |à 6 Pagescontribute positively to their care. The fractured, ineffective care Mrs. Lushko received is disappointing, however, this case provides strong support for a shift in focus towards managed care and specifically, the Accountable Care Organization structure. The following details several aspects of Mrs. Lushkoââ¬â¢s experience and how her care could have been improved by enrollment in BCBS of Illinoisââ¬â¢ private ACO plan. 1. 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